Centessa Pharmaceuticals plc shared details on its upcoming oral presentation at World Sleep Congress 2023, which will focus on ORX750, a drug in preclinical development for the treatment of narcolepsy and other sleep disorders.

“We believe ORX750 has the potential to be a best-in-class therapy to treat narcolepsy and other sleep disorders, and we are thrilled with the opportunity to share preclinical data in an oral presentation at the World Sleep Congress,” says Saurabh Saha, MD, PhD, CEO of Centessa, in a release.

Details of the presentation are as follows:
Title: ORX750, an Oral Selective Orexin Receptor 2 Agonist, Promotes Wakefulness and Reduces Cataplexy in the Orexin/Ataxin-3 Mouse
Link to abstract: https://ws2023.abstractserver.com/program/#/details/presentations/1347
Ref number: O25
Authors: Sarah Wurts Black, Tod Steinfeld, Karl Gibson, Gregory R. Ott, Emiliangelo Ratti, David Grainger, Mario Alberto Accardi, and Deborah S. Hartman
Oral presentation: Wednesday, Oct 25, at 10:45 am (local time)

According to the abstract, preclinical data shows ORX750 has the potential to treat patients with primary symptoms of narcolepsy type 1, as well as reduce excessive sleepiness in those presenting sleep/wake disorders with normal orexin levels.

In addition, Sarah Wurts Black, PhD, head of biology for Centessa’s orexin program, will co-chair a symposium at the congress focused on the development of orexin receptor agonists. ORX750 is an orally administered, selective orexin receptor 2 agonist.

Details of the presentation are as follows: 

Symposium: Development of hypocretin/orexin receptor agonists: a progress report (co-chairs Sarah Wurts Black and Thomas S. Kilduff)
Link to symposium abstract: https://ws2023.abstractserver.com/program/#/details/sessions/315
Title: Approaches to the discovery and development of hypocretin/orexin receptor agonists
Ref number: S56
Speaker: Sarah Wurts Black
Session details: Tuesday, Oct 24, at 3:22 pm (local time)

Centessa plans to make its presentation available on the Centessa website after the presentations conclude.

Photo 76645204 © Kiosea39 | Dreamstime.com