treadmillResearch led by Queen Mary, University of London, has shown that recovery from chronic fatigue syndrome (CFS) is possible for some patients, and has identified two treatments most likely to lead to recovery.

The latest results from the PACE trial show that cognitive behavior therapy (CBT) and graded exercise therapy (GET), as supplements to specialist medical care, increase the likelihood of recovery from CFS three-fold compared to other treatments studied. The trial, carried out in collaboration with researchers from King’s College London, the University of Oxford, and the Medical Research Council (MRC), is published in Psychological Medicine.

The researchers studied 640 participants with CFS who were randomized into one of four treatment groups:

• Specialist medical care (SMC) alone;
• SMC plus adaptive pacing therapy (APT);
• SMC plus cognitive behavioral therapy (CBT);
• SMC plus graded exercise therapy (GET)

Evidence for recovery was assessed one year after participants were randomly allocated to treatments.

Previous published results showed that both CBT and GET led to greater reductions in symptoms and disability than either APT or SMC. In this analysis, the researchers have gone a step further and examined how many patients had recovered from their illness after these treatments. Patients were classified as recovered if they no longer met several criteria for ill health that  were initially used to define eligibility for the trial. These included not suffering from significant fatigue or physical disability, and no longer meeting diagnostic criteria for CFS. Patients also had to rate themselves as being “much” or “very much better” in their overall health.

The findings showed that those who received CBT or GET, in addition to SMC, were three times more likely to meet the criteria for recovery than those receiving SMC alone or in combination with APT. Overall, 22% of those who received either CBT or GET, in addition to SMC, met the criteria for recovery, compared to 8% after APT in addition to SMC, and 7% after SMC alone. There were similar patterns of recovery however CFS was defined, including those who were diagnosed as having myalgic encephalomyelitis (ME), thought by some to be the same as CFS and by others as being different.