Psychology Today examines how the blend of chemicals in the cannabis plant acts within the brains of people with restless leg syndrome.
Recent studies have shown that chronic cannabis use is associated with reduced dopamine synthesis capacity. Thus, the efficacy of cannabis in patients with Restless Leg Syndrome may be due to its ability to prevent the excessive release of dopamine and restore normal neural activity in the basal ganglia.
It is too soon to claim that we understand the role of the brain’s endogenous cannabis system in Restless Leg Syndrome. However, as more information accumulates it might one day be possible to design effective cannabis-like drugs for a variety of human disorders of the brain.