According to research published in the American Journal of Respiratory and Critical Care Medicine, mandibular advancement devices may help reduce a patient’s risk of cardiovascular disease.
The researchers found MAD therapy significantly improved the apnea-hypopnea index (AHI) scores, micro-arousal index scores, and symptoms of snoring, fatigue, and sleepiness. However, MAD did not improve endothelial function, a key predictor of cardiovascular disease, or lower blood pressure.
Continuous positive airway pressure, or CPAP, is considered the “gold standard” of obstructive sleep apnea treatment. However, many patients find it uncomfortable, and MAD is the most commonly prescribed alternative.
“Endothelial dysfunction is one of the intermediate mechanisms that potentially contribute to the increased risk of cardiovascular disease in OSA,” said lead study author Frédéric Gagnadoux, MD, professor of pulmonology at the University Hospital of Angers in France. “Whether MAD therapy improves endothelial function in OSA patients had not been evaluated before in properly controlled and adequately powered trials.”
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