Onabotulinum toxin-A (BoNT-A) injections can improve sleep bruxism, according to a new study, reports Physician’s Briefing.
William G. Ondo, M.D., from the Methodist Neurological Institute in Houston, and colleagues recruited 31 patients aged 18 to 85 years with clinically diagnosed sleep bruxism confirmed by polysomnography. Twenty-three patients were randomized to either BoNT-A injection (13 patients) or placebo (10 patients; nine completed the study).
Participants were assessed at four to eight weeks after the initial treatment visit. The researchers found that clinical global impression (P < 0.05) and visual analog scale of change (P < 0.05) in bruxism and in pain favored the BoNT-A group.