Sleep deprivation can alter your DNA and potentially lead to disease, according to a new study.
In a study carried out in collaboration by the University of Helsinki, the National Institute for Health and Welfare and the Finnish Institute of Occupational Health, men between 25 and 55 years of age suffering from insufficient sleep were compared to healthy men who get enough sleep. Altogether 105 men took part in the study.
DNA was extracted from blood leukocytes collected from the study subjects, to determine the methylation levels of nearly half a million CpG bases. DNA methylation is among what are known as epigenetic mechanisms, impacting gene expression and, thus, the functioning of cells and tissues.
“Based on our findings, no single DNA methylation element significantly differed between those suffering from a lack of sleep and healthy control subjects. However, the analysis of molecular networks revealed that insufficient sleep resulted in changes in DNA methylation in the gene regulatory elements belonging to the nervous system development pathway,” explains Professor Tiina Paunio, who headed the study.
The findings indicate that lack of sleep is associated with systemic DNA alterations that affect the genome. “We are currently looking into how permanent these changes are. In addition, we are interested in how they are linked with the long-term health risks of sleep deprivation,” Paunio says.