The care provided by a mother can impact the body clock and health of offspring after birth, according to new research. By reducing abnormalities in the body clock of offspring, it may be possible to develop therapies for serious lifestyle-related diseases, such as heart disease and obesity.
The mother-offspring interaction is very important for health later in adulthood. This study, published in The Journal of Physiology, provides compelling evidence that the circadian characteristics of a mother may positively affect the likelihood of disease developing in offspring. Providing better maternal care significantly reduced abnormalities in the circadian system and resulted in a lower likelihood of development of heart disease.
The study conducted by the Institute of Physiology of the Czech Academy of Sciences was performed in two strains of laboratory rats, in which the maternal care and synchrony of their circadian clocks with external day/night cycle differed. The effect of maternal care provided by the genetic mother of these pups was compared with maternal care of the foster mother. The pups either had an aberrant circadian system and were genetically determined to develop disease in adulthood or they were healthy controls. The researchers tested the effect of maternal care on the body clock before and just after weaning, and on their activity rhythms, heart rate and blood pressure in adulthood. Proper maternal care provided to pups genetically predisposed to develop disease led to improvement of their clock function and abolished the rise in their heart rate in adulthood.
The data obtained in pups before weaning were based on population samples because the researchers could not assess circadian rhythms of the clocks in each individual pup within the body without disturbing maternal behaviour. Additionally, in the rat strain spontaneously developing disease, the molecular mechanisms connecting the circadian clock and the pathology is not understood.
Alena Sumova, corresponding author for the study, says in a release, “These results point to a real possibility to reduce abnormalities in the offspring’s body clock and therefore limit the progression of disease in order to improve health. Our future research will be directed at understanding in more detail how an aberrant circadian system contributes to the progression of disease. We believe that this research is worth future explorations as it may provide novel therapies for serious lifestyle related diseases in humans.”