Your sleep problems may be improved if you try an Indian herb, Ashwagandha. Researchers at University of Tsukuba in Japan found that an active component of Ashwagandha leaves significantly induces sleep.
Ashwagandha (Withania somnifera) is a central herb in Ayurveda, the traditional home medicine native to India. As signified by its Latin name somnifera, meaning sleep-inducing, it has been recommended for sound sleep through centuries. Even though scientific studies also support that crude powder of Ashwagandha promotes sleep, the active component with sleep-inducing property remains unknown.
The research group led by Mahesh K. Kaushik and Yoshihiro Urade of the International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, investigated the effect of various components of Ashwaganda on sleep in mice by recording electroencephalogram and electromyography. The water extract of Ashwaganda leaf containing rich in triethylene glycol (TEG) promoted non-rapid eye movement (NREM) sleep significantly and changed rapid eye movement (REM) sleep slightly, while the alcoholic extract containing active withanolides showed no effect on sleep. The sleep induced by TEG was similar to normal sleep. Furthermore, commercially available TEG also increased the amount of NREM sleep. They thus concluded that TEG is the active component that induces physiologically sound sleep.
The findings in this study could revolutionize the natural plant-based therapies for insomnia and sleep-related disorders, the authors say.
However, the clinical application of TEG to treat insomnia is still in the immature status, because the TEG is primarily used for industrial purpose and very little is known about its applicability and toxicity to the biological systems. Further studies will thus be needed to confirm the safety of TEG.
According to the authors, they are currently evaluating the effect of TEG administration on stress, because Ashwagandha is believed to mitigate stress and correct imbalance of various nervous systems. Future studies also include the identification of target brain area of TEG, its BBB permeability, and the mechanism through which TEG induces sleep.
The study is published in PLOS One.
Photo credit: University of Tsukuba