Hot flashes and nocturia may drive the association between androgen deprivation therapy and sleep disturbance among men with prostate cancer, reports Healio.

“We were trying to better understand how common sleep disturbance is and what might be causing it among men treated with hormonal therapy for prostate cancer, Brian D. Gonzalez, PhD, assistant member of Moffitt Cancer Center in Tampa, Florida, told HemOnc Today. “We wanted to find whether the hot flashes and greater need to urinate overnight (i.e., nocturia) commonly seen in men receiving this treatment might help explain their worse difficulty sleeping.”

The researchers evaluated men either before or within 1 month of beginning ADT, and again at 6 and 12 months later (n = 78). They also assessed patients who were treated only with prostatectomy (n = 99) and matched controls with no cancer history (n = 108).

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