A study published in Translational Psychiatry aimed to examine the biomarkers associated with changes in hypersomnia and insomnia and as predictors of improvements in sleep quality.

Sleep disturbances can present as either insomnia or hypersomnia in MDD, with hypersomnia as a defining symptom of atypical depression. Distinguishing between atypical and melancholic depression has important clinical relevance as differential treatment responses have been observed in patients with atypical features.13, 14, 15 However, previous research of these biological correlates of sleep disturbances is limited in that it does not distinguish between insomnia and hypersomnia. Identification of biomarkers that uniquely predict or correlate with improvements in hypersomnia and insomnia is an important step toward more effective treatment of MDD.

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