Healthline: Right now, there’s extremely limited research on CBD and RLS. Here’s what we know so far.
It’s possible RLS is associated with a disruption in the dopamine pathways in the brain.
A 2019 study that looked at smoking cannabis and its effects on RLS showed that chronic cannabis use is linked with lowered dopamine synthesis capacity, which may explain the reported effectiveness of cannabis in RLS.
A 2021 study that looked at reasons for CBD use showed that 5 percent of people in the study used it for RLS.
Other anecdotal evidence also suggests some people may find relief from RLS with CBD.