Research topics include sleep latency mechanisms, genetic variants related to sleep-wake phases, and genome sequencing in insomnia patients.

Summary: Vanda Pharmaceuticals Inc announced its participation at SLEEP 2024, where it will present various research findings related to sleep disorders, including studies on sleep latency in zebrafish, genetic variants associated with sleep-wake phase disorders, and whole genome sequencing in insomnia patients. Sandra Paulina Smieszek, PhD, head of genetics, will present these findings.

Key Takeaways:

  • Melanopsin and Sleep Latency: Vanda Pharmaceuticals will present research on how alterations in melanopsin affect sleep latency in zebrafish.
  • Genetic Insights into Sleep-Wake Disorders: A study examining genetic variants linked to dim light melatonin onset in individuals with delayed sleep-wake phase disorder will be showcased.
  • Whole Genome Sequencing in Insomnia: The company will also share findings from a whole genome sequencing study that identifies genetic variants associated with total sleep time and latency to persistent sleep in insomnia patients.

Vanda Pharmaceuticals Inc announced its participation at SLEEP 2024, where it will present research on topics including sleep latency in zebrafish and genetic variants associated with sleep disorders.

Research to be presented at SLEEP 2024 on June 4 by Sandra Paulina Smieszek, PhD, head of genetics, is as follows: 

  • Presentation Title: “Melanopsin crispants in zebrafish display difference in sleep latency”
    • Poster Presentation Session: P-17
    • Poster Number: 11
  • Presentation Title: “Genetic variants associated with dim light melatonin onset in a delayed sleep-wake phase disorder cohort”
    • Poster Presentation Session: P-22
    • Poster Number: 146
  • Presentation Title: “Genetic variants associated with TST and LPS in insomnia patients: whole genome sequencing study”
    • Poster Presentation Session: Late-Breaking Abstracts (LBA); P-31
    • Poster Number: 451
  • Presentation Title: “Drug screening and CRISPR/Cas9 screening of HCN channels”
    • Poster Presentation Session: P-17
    • Poster Number: 10