New research by University of Georgia scientists sheds light on why people with obstructive sleep apnea may have associated autoimmune disorders. The results could lead to better approaches to treatment and possibly new drug therapies.
The study, led by Bradley Phillips, PharmD, BCPS, FCCP, builds on previous research showing that obstructive sleep apnea (OSA) increases the risk for autoimmune diseases. Immune system disorders are a result of either low activity or over activity of the immune system and include well-known conditions such as lupus and rheumatoid arthritis. The molecular links to autoimmunity are poorly understood.
“This paper looks at what may be the underlying mechanisms that increase someone’s risk for autoimmune disorders because they have untreated obstructive sleep apnea,” says Phillips, director of UGA’s Biomedical and Health Sciences Institute, in a release.
Phillips and the team looked at four cytokines—proteins involved in cell signaling—associated with autoimmune disease. They evaluated the cytokines in three groups of adults: patients with untreated OSA, patients with OSA who were receiving treatment, and people who did not have OSA. The study results revealed abnormal levels of the four cytokines in patients with untreated sleep apnea, suggesting that poor sleep and inadequate oxygen supply may affect the cytokines.
This study, published in Clinical Immunology, is one of four investigating possible links between obstructive sleep apnea and specific diseases. In addition to autoimmune disorders, the team is also looking at neurodegenerative disorders, cardiovascular disease, and renal disease.
“The relationship between OSA and other diseases is always complex to study. OSA in adults is commonly first diagnosed in midlife, but increases with age,” says Phillips, who is also professor in the College of Pharmacy. “With increased age, you are also at risk for other diseases, and it’s very challenging for clinicians and researchers to determine if it’s OSA alone that causes other disorders, or if OSA only worsens the severity and progression of an underlying disease. In the case of high blood pressure, we know untreated OSA can cause hypertension and make blood pressure drug therapy ineffective. If obstructive sleep apnea is a key player, then it should be evaluated and treated along with other conditions.”