An HCP Live report indicates a new study suggests pregabalin shows notable improvements in pain-related interference of sleep related to low back pain.

For the primary endpoint, pregabalin resulted in significantly greater improvements in PRSIS at week eight and at week four. Relative to usual care at week eight, pregabalin improved pain and function (both P<0.001), and showed global improvements since beginning study medication (P<0.001).“The significant improvements in sleep and pain are not surprising given the reciprocal relationship between these two outcomes such that not only does pain interfere with sleep but poor sleep increases pain sensitivity,” the study authors continued. “Additionally, it has been suggested that improvements in function and health state in patients treated with pregabalin are not exclusively mediated through analgesic efficacy, but rather result from combined effects on pain and sleep interference.”